Azithromycin is an antibiotic that fights bacteria. Azithromycin is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, eye infections, and sexually transmitted diseases. To evaluate the safety of long-term azithromycin use in CLD patients, we collected randomized controlled trials evaluating the microbiological changes and azithromycin-related adverse events among patients receiving long-term therapy. Had my appointment at the hospital now and I have a few areas of very mild bronchiectasis. I have been prescribed long term Azithromycin. The effect after a week is wonderful stopped the cough and the pain and energy levels right back up to near normal for me. Azithromycin oral tablet doesn’t cause drowsiness but it can cause other side effects. More common side effects. The more common side effects of azithromycin oral tablet can include: The upside of this is I've been looking into side effects of long-term antibiotic use that I've encountered since taking the massive doses that the LLMDs prefer and in combinations unheard of for any other disease of which I'm aware. Patients considered eligible for long-term low-dose azithromycin were those who, despite optimization of standard care, experienced ≥3 infective exacerbations in the previous 6 months. The benefits of long-term prophylaxis must be weighed according to the patient’s condition against the risk of cardiovascular side effects and others. 2. Acute bacterial sinusitis due to H. influenzae, M. catarrhalis, or S. pneumoniae. Study design. Retrospective analysis of data for the year before initiation of long-term azithromycin therapy (for 12 months) in patients with severe COPD was undertaken in order to assess the clinical benefits of this treatment to reduce AECOPD frequency. Includes indications, proper use, special instructions, precautions, and possible side effects. Easy-to-read patient leaflet for Azithromycin Injection. Skip to Content Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Sneid on long term effects of azithromycin: Kidney and liver testing at intervals. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Sneid on long term effects of azithromycin: Kidney and liver testing at intervals..